Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.

@article{Babaya2003AssociationOI,
  title={Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.},
  author={Naru Babaya and Hiroshi Ikegami and Tomomi Fujisawa and Koji Nojima and Michiko Itoi-Babaya and Kaori Inoue and Jun Nakura and Michiko Abe and Miyuki Yamamoto and Jin Ji Jin and Zhihong Wu and Tetsuro Miki and Masakatsu Fukuda and Toshio Ogihara},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 6},
  pages={
          2548-51
        }
}
The serum level of high-density lipoprotein cholesterol (HDL-c), which protects against the development of atherosclerosis, is under genetic control. However, the genetic components responsible for the serum HDL-c level are yet to be determined. A recent knockout mouse study demonstrated that hepatocyte nuclear factor-1 alpha (HNF-1 alpha) is an essential transcriptional regulator of HDL-c metabolism. In this study, the association of an HNF-1 alpha gene polymorphism, isoleucine (Ile) 27… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Similar Papers

Loading similar papers…