Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study

@inproceedings{Huber2019AssociationOH,
  title={Association of Human FOS Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study},
  author={Ren{\'e} Huber and Holger Kirsten and Annu N{\"a}kki and Dirk Pohlers and Hansj{\"o}rg Thude and Thorsten Eidner and Matthias Heinig and Korbinian Brand and Peter Ahnert and Raimund W. Kinne},
  booktitle={International journal of molecular sciences},
  year={2019}
}
Our aim was to analyse (i) the presence of single nucleotide polymorphisms (SNPs) in the JUN and FOS core promoters in patients with rheumatoid arthritis (RA), knee-osteoarthritis (OA), and normal controls (NC); (ii) their functional influence on JUN/FOS transcription levels; and (iii) their associations with the occurrence of RA or knee-OA. JUN and FOS promoter SNPs were identified in an initial screening population using the Non-Isotopic RNase Cleavage Assay (NIRCA); their functional… CONTINUE READING

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