Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women

@article{Urano2009AssociationOH,
  title={Association of HTRA1 promoter polymorphism with spinal disc degeneration in Japanese women},
  author={Tomohiko Urano and Ken’ichiro Narusawa and Satomi Kobayashi and M Shiraki and Kuniko Horie-Inoue and Noriko Sasaki and Takayuki Hosoi and Yasuyoshi Ouchi and Toshitaka Nakamura and Satoshi Inoue},
  journal={Journal of Bone and Mineral Metabolism},
  year={2009},
  volume={28},
  pages={220-226}
}
HTRA1 (high-temperature requirement A1) has been implicated in the modulation of various disease pathologies. HTRA1 expression is upregulated in osteoarthritic joints, suggesting that it may contribute to the development of this debilitating disease. Moreover, recent reports have shown that the rs11200638, a single nucleotide polymorphism (SNP) in the promoter region of the HTRA1 gene, is strongly associated with an increased prevalence of age-related macular degeneration (AMD). In the present… CONTINUE READING

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