Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.

@article{Shimodaira2010AssociationOH,
  title={Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.},
  author={Masanori Shimodaira and Tomohiro Nakayama and Naoyuki Sato and Noriko Aoi and Mikano Sato and Yoichi Izumi and Masayoshi Soma and Koichi Matsumoto},
  journal={European journal of endocrinology},
  year={2010},
  volume={163 4},
  pages={671-80}
}
BACKGROUND HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by affecting the aldosterone level. METHODS We performed a haplotype- and diplotype-based case-control study to investigate the association between the HSD3B gene variations and essential hypertension (EH), aldosterone level, and left ventricular hypertrophy (LVH). A total of 275 EH patients and 286… CONTINUE READING

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