Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.

@article{Robbins2008AssociationOH,
  title={Association of HPC2/ELAC2 and RNASEL non-synonymous variants with prostate cancer risk in African American familial and sporadic cases.},
  author={Christiane M. Robbins and Wenndy Hernandez and Chiledum Ahaghotu and James K. Bennett and Gerald P. Hoke and Terry W. Mason and Curtis A. Pettaway and Srinivasan Vijayakumar and Sally Weinrich and Paulette M Furbert-Harris and Georgia M. Dunston and Isaac J. Powell and John D. Carpten and Rick A Kittles},
  journal={The Prostate},
  year={2008},
  volume={68 16},
  pages={
          1790-7
        }
}
INTRODUCTION The RNASEL and HPC2/ELAC2 genes have been implicated in hereditary prostate cancer. Further assessment of the role of these genes in sporadic prostate cancer in African American men (AAM) is warranted. METHODS Genotyping of HPC2/ELAC2 variants (S217L, A541T), along with RNASEL variants (R462Q and E541D) was completed in 155 African American sporadic and 88 familial prostate cancer cases, and 296 healthy male controls. Logistic regression analysis was performed and odds ratios (OR… CONTINUE READING
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