Association of HLA profiles with early plasma viral load, CD4+ cell count and rate of progression to AIDS following acute HIV-1 infection. Multicenter AIDS Cohort Study.

@article{Saah1998AssociationOH,
  title={Association of HLA profiles with early plasma viral load, CD4+ cell count and rate of progression to AIDS following acute HIV-1 infection. Multicenter AIDS Cohort Study.},
  author={Alfred J. Saah and Donald R Hoover and S Weng and Mary N Carrington and John W Mellors and Charles R. Rinaldo and Douglas Mann and Raymond Apple and John P. Phair and Roger Detels and Steve O'Brien and C. Enger and Peter E. Johnson and Richard A. Kaslow},
  journal={AIDS},
  year={1998},
  volume={12 16},
  pages={2107-13}
}
BACKGROUND Host genetic factors, such as HLA alleles, play an important role in mediating the course of HIV-1 disease progression through largely undefined mechanisms. OBJECTIVES To examine the association of HLA markers with HIV-1 RNA plasma viral load and other factors associated with course of disease progression in HIV-1 infection. DESIGN AND METHODS A group of 139 HIV-1 seroconverters from the Multicenter AIDS Cohort Study had been typed for a variety of HLA markers. HIV-1 RNA plasma… CONTINUE READING