Association of HLA-G 3' UTR 14-bp insertion/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population.

@article{Jiang2011AssociationOH,
  title={Association of HLA-G 3' UTR 14-bp insertion/deletion polymorphism with hepatocellular carcinoma susceptibility in a Chinese population.},
  author={Yuting Jiang and Shougong Chen and Shasha Jia and Zhansheng Zhu and Xueren Gao and Dong Dong and Yuzhen Gao},
  journal={DNA and cell biology},
  year={2011},
  volume={30 12},
  pages={1027-32}
}
The 14-bp insertion/deletion (indel) polymorphism located in the 3' UTR of the human leukocyte antigen-G (HLA-G) gene plays a role in several autoimmune and chronic inflammatory diseases. HLA-G expression is associated with hepatocellular carcinoma (HCC) prognosis, especially in early stage, with high expression independently associated with shortened overall survival and increased tumor recurrence. In the present study, we carried out a case-control study in a Chinese population (318 cases and… CONTINUE READING