Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors.

@article{Gao2002AssociationOH,
  title={Association of H19 promoter methylation with the expression of H19 and IGF-II genes in adrenocortical tumors.},
  author={Zhi-He Gao and Suvikki Suppola and Jianqi Liu and P{\"a}ivi Heikkil{\"a} and Juhani E J{\"a}nne and Raimo Voutilainen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2002},
  volume={87 3},
  pages={1170-6}
}
Low H19 and abundant IGF-II expression may have a role in the development of adrenocortical carcinomas. In the mouse, the H19 promoter area has been found to be methylated when transcription of the H19 gene is silent and unmethylated when it is active. We used PCR-based methylation analysis and bisulfite genomic sequencing to study the cytosine methylation status of the H19 promoter region in 16 normal adrenals and 30 pathological adrenocortical samples. PCR-based analysis showed higher… CONTINUE READING
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Igf 2 imprinting does not require its own DNA methylation or H 19 RNA

  • AC Bell, G Felsenfeld
  • Genes Dev
  • 2000

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