Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.

@article{BurgueteGarca2010AssociationOG,
  title={Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study.},
  author={Ana Isabel Burguete-Garc{\'i}a and Miguel Cruz-L{\'o}pez and Vicente Madrid-Marina and Ruy L{\'o}pez-Ridaura and Mauricio H{\'e}rnandez-Avila and Bernardo Cortina and Rosa Estela L{\'o}pez G{\'o}mez and Eduardo Velasco-Mondrag{\'o}n},
  journal={Metabolism: clinical and experimental},
  year={2010},
  volume={59 1},
  pages={38-45}
}
Type 2 diabetes mellitus (T2D) is a main public health problem in the Mexican population. It is characterized by insulin resistance in peripheral tissues and a relative deficiency in the pancreatic beta-cell functions. Diverse single nucleotide polymorphisms (SNPs) of the IRS1 gene have been associated with insulin resistance and T2D risk. The aim of this study was to identify the association between known IRS1 polymorphisms (Pro512Ala, Asn1137Asp, Gly972Arg, and Arg158Pro) in a sample of… CONTINUE READING
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