Association of GSTP1 CpG Islands Hypermethylation with Poor Prognosis in Human Breast Cancers

@article{Arai2006AssociationOG,
  title={Association of GSTP1 CpG Islands Hypermethylation with Poor Prognosis in Human Breast Cancers},
  author={Takashi Arai and Yasuo Miyoshi and Seung Jin Kim and Tetsuya Taguchi and Yasuhiro Tamaki and Shinzaburo Noguchi},
  journal={Breast Cancer Research and Treatment},
  year={2006},
  volume={100},
  pages={169-176}
}
Glutathione S-transferase P1 (GSTP1) belongs to a family of phase II metabolic enzymes that can detoxify the carcinogens and cytotoxic drugs by conjugating them with glutathione. Relationship of GSTP1 CpG islands hypermethylation or GSTP1 protein expression with clinicopathological characteristics of breast cancers was studied. The CpG islands hypermethylation status of GSTP1 gene was studied by methylation specific primer assay and GSTP1 expression was studied by immunohistochemistry in… CONTINUE READING

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