Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension

@article{Speirs2004AssociationOG,
  title={Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension},
  author={Helen Speirs and K Katyk and Natasha N. Kumar and Adam V. Benjafield and William YS Wang and Brian J. Morris},
  journal={Journal of Hypertension},
  year={2004},
  volume={22},
  pages={931-936}
}
Objective: To perform association studies of polymorphisms of the potential candidate essential hypertension (HT) genes GRK4, PTP1B and HSD3B1. Methods: Subjects consisted of 168 unrelated, Caucasian essential hypertensive (HT) patients and 312 normotensive (NT) controls. Biological power was increased by ensuring subjects in each group had parents with the same blood pressure (BP) status as theirs. Three GRK4γ variants (R65L, A142V and A486V), one HSD3B1 variant (T←C Leu338) and one PTP1B… 
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G PROTEIN RECEPTOR KINASE 4 ( GRK 4 ) POLYMORPHISMS : BETA-BLOCKER PHARMACOGENETICS AND TREATMENT RELATED OUTCOMES IN HYPERTENSION
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TLDR
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TLDR
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Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure.
BACKGROUND HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by
Variants in Genes Involved in Functional Pathways Associated with Hypertension in African Americans
TLDR
Results show very modest effects and do not fully replicate previous studies, but if variants in the G‐protein coupled receptor Kinase‐4, nitric oxide synthase‐3, or angiotensin converting enzyme (ACE) genes are associated singly or through complex interactions, with HBP in African Americans aged 18–49 years is determined.
Association Study of G Protein‐Coupled Receptor Kinase 4 Gene Variants with Essential Hypertension in Northern Han Chinese
TLDR
A total of 6 haplotypes were observed in the entire population, with the haplotypes L‐V‐A and R‐A‐A being found to be significantly related to hypertension (P= 0.001), and the A486 allele showed a significant association with HT.
Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure.
TLDR
No evidence is found to support confirmation that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD2B1 affects blood pressure or hypertension, favoring the hypothesis that all adrenocortical steroidogenesis is primarily dependent on the type II 3β-hydroxysteroid dehydrogenase.
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