Association of G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients.

@article{Kim2008AssociationOG,
  title={Association of G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients.},
  author={C D Kim and Hye-Myung Ryu and Ji-Young Choi and Hee-Jeong Choi and Hyuk-Joon Choi and Ji-Hyung Cho and Sun Hee Park and Dong-Il Won and Yong Lim Kim},
  journal={Transplantation},
  year={2008},
  volume={86 11},
  pages={1610-4}
}
BACKGROUND Interleukin 18 (IL-18) is a potent proinflammatory cytokine, which is postulated to play a role in mechanism of renal allograft rejection and strongly induces interferon (IFN)-gamma production. The aim of this study was to investigate the association of the G-137C IL-18 promoter polymorphism with acute allograft rejection in renal transplant recipients (RTRs). METHODS A total of 226 RTRs and 148 controls were recruited for association analysis. Genotyping was performed by using a… CONTINUE READING

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