Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients.

  title={Association of Foxp3 rs3761548 polymorphism with cytokines concentration in gastric adenocarcinoma patients.},
  author={Rana Ezzeddini and Mohammad hosein Somi and Mohammad Taghikhani and Seyyed-Yaghoub Moaddab and Kourosh Masnadi Shirazi and Masoud Shirmohammadi and Amir Taher Eftekharsadat and Bizhan Sadighi Moghaddam and Amir Salek Farrokhi},
T regulatory cells (Tregs) and related-cytokines are effectively engaged in the process of tumor immune escape and functionally inhibit immune response against the tumor. This study aimed to investigate the association of Foxp3 gene single nucleotide polymorphism (SNP) (rs3761548) with serum IL-35, IL-10, and TGF-β levels in gastric adenocarcinoma (GA) patients. The blood samples were obtained from 150 GA patients and 166 control subjects. The polymerase chain reaction-restriction fragment… 


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