Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese

@article{Hatta1999AssociationOF,
  title={Association of Fcγ receptor IIIB, but not of Fcγ receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese},
  author={Yoshihiro Hatta and Naoyuki Tsuchiya and Jun Ohashi and Masakazu Matsushita and Kensuke Fujiwara and Koichi Hagiwara and Takeo Juji and Katsushi Tokunaga},
  journal={Genes and Immunity},
  year={1999},
  volume={1},
  pages={53-60}
}
Human Fcγ receptor (FcγR) genes form a clustered gene family on chromosome 1q21–24. Although the association of FcγR polymorphisms with systemic lupus erythematosus (SLE) has been extensively studied, the results are often contradictory. In this study, FcγRIIA-131H/R, FcγRIIIA-176F/V and FcγRIIIB-NA1/2 genotypes were determined in the Japanese patients with SLE (n = 81) or rheumatoid arthritis (RA, n = 115) as well as in healthy individuals (n = 217), and possible association with the disease… CONTINUE READING