Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.

@article{Ouma2006AssociationOF,
  title={Association of FCgamma receptor IIA (CD32) polymorphism with malarial anemia and high-density parasitemia in infants and young children.},
  author={Collins Ouma and Christopher C. Keller and Dorothy A Opondo and Tom Were and Richard O Otieno and Michael Frederick Otieno and Alloys S S Orago and John Michael Ong'echa and John Vulule and Robert E. Ferrell and Douglas J Perkins},
  journal={The American journal of tropical medicine and hygiene},
  year={2006},
  volume={74 4},
  pages={573-7}
}
Protective immunity against Plasmodium falciparum is partially mediated through binding of malaria-specific IgG antibodies to Fcgamma receptors. Polymorphic variability in Fcgamma RIIa (H/R-131) is associated with differential binding of IgG subtypes and malaria disease outcomes. However, the role of Fcgamma RIIa-131 variability in conditioning susceptibility to severe malarial anemia, the primary manifestation of severe malaria in holoendemic P. falciparum transmission areas, is largely… CONTINUE READING