Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants.

@article{Mariani2017AssociationOD,
  title={Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants.},
  author={Thomas J. Mariani and Xing Qiu and ChinYi Chu and L L Wang and Juilee Thakar and Jeanne Holden-Wiltse and Anthony M Corbett and David J. Topham and Ann R. Falsey and Mary T. Caserta and Edward E. Walsh},
  journal={The Journal of infectious diseases},
  year={2017},
  volume={216 8},
  pages={1027-1037}
}
Background Nearly all children are infected with respiratory syncytial virus (RSV) within the first 2 years of life, with a minority developing severe disease (1%-3% hospitalized). We hypothesized that an assessment of the adaptive immune system, using CD4+ T-lymphocyte transcriptomics, would identify gene expression correlates of disease severity… CONTINUE READING