Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study.

@article{Mattey2007AssociationOD,
  title={Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study.},
  author={Derek L. Mattey and W. Douglas Thomson and William E. R. Ollier and Mike Batley and Paul G. Davies and Andrew K S Gough and James Anthony Joseph Devlin and Peter Prouse and David Willis James and Peter J Leb Williams and Josh J Dixey and John Winfield and Nancy Lynne Cox and Gouri M Koduri and Adam Young},
  journal={Arthritis and rheumatism},
  year={2007},
  volume={56 5},
  pages={
          1408-16
        }
}
OBJECTIVE To determine whether the HLA-DRB1 shared epitope (SE) is associated with early mortality and specific causes of death in rheumatoid arthritis (RA). METHODS HLA-DRB1 genotyping was carried out on blood samples from 767 patients recruited for the Early RA Study (ERAS), a multicenter, inception cohort study with followup over 18 years. Dates and causes of death (n = 186) were obtained from the Office of National Statistics. The association of HLA-DRB1 alleles with risk of mortality was… CONTINUE READING
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