Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population.

@article{Petrone2001AssociationOD,
  title={Association of DRB1*04-DQB1*0301 haplotype and lack of association of two polymorphic sites at CTLA-4 gene with Hashimoto's thyroiditis in an Italian population.},
  author={Antonio Petrone and Gabriele Giorgi and C A Mesturino and Marco Capizzi and Isabella Cascino and Lorenza Nistic{\'o} and John Osborn and Umberto di Mario and Raffaella Buzzetti},
  journal={Thyroid : official journal of the American Thyroid Association},
  year={2001},
  volume={11 2},
  pages={171-5}
}
Hashimoto's thyroiditis (HT) is an autoimmune disease resulting from a complex interaction between genetic and environmental factors. The genetic loci conferring susceptibility need to be still defined. The aim of the present study was to determine whether Cytotoxic T-Lymphocyte-Associated Antigen-4 (CTLA-4), HLA DRB1, and DQB1 genes were associated to HT in an Italian population. We evaluated the allele distribution of the following loci: CTLA-4 exon 1 A49G dimorphism, which resulted in an… CONTINUE READING
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