Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia

@article{Thibaut1997AssociationOD,
  title={Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia},
  author={Florence Thibaut and Jean Marie Ribeyre and Nathalie Dourmap and Rolando Meloni and Claudine Laurent and Dominique Campion and Jean François M{\'e}nard and Sonia Dollfus and Jacques Mallet and Michel Petit},
  journal={Schizophrenia Research},
  year={1997},
  volume={23},
  pages={259-264}
}
Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia
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During treatment with antipsychotic drugs patients with the rare allele displayed lower plasma homovanillic acid and 3-methoxy-4-hydroxyphenylglycol levels than those without.
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TLDR
The finding suggests that the TH10 allele may be a liability factor for positive schizophrenia in the Korean population.
[Association of the tyrosine hydroxylase gene polymorphism with schizophrenia in the population of central Poland].
TLDR
Differences in the susceptibility to schizophrenia depending on polymorphic allele variants in repetitive TCAT sequence in TH01 locus may be associated with the function of a regulatory element in the process of TH gene transcription.
Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.
TLDR
This study indicates that the TH gene is not likely to play a major role in the genetic predisposition to schizophrenia, mood disorders, or alcohol dependence.
An association of the polymorphic repeat of tetranucleotide (TCAT) in the first intron of the human tyrosine hydroxylase gene with schizophrenia in a Japanese sample
TLDR
It is suggested that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.
Association Analysis of Two Tyrosine Hydroxylase Gene Polymorphisms in Normotensive Offspring from Hypertensive Families
TLDR
The studied TH polymorphisms do not appear to be associated with family history of essential hypertension, Nevertheless, some genotypes of TH might be related to disturbance of plasma noradrenaline concentration.
Exon 3 of tyrosine hydroxylase gene: lack of association with Japanese schizophrenic patients
TLDR
The results indicate that exon 3 of the human TH gene lacks association with schizophrenia in Japanese patients, and any mutation changing the amino acid sequence Gly36-Arg37-Arg38 would result in the elevation of DA synthesis.
Post-genomic era and gene discovery for psychiatric diseases: There is a new art of the trade?
The microsatellite HUMTH01, located in the first intron of the Tyrosine Hydroxylase (TH) gene (encoding the rate-limiting enzyme in the synthesis of catecholamines), is characterized by a TCAT
Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia
TLDR
A meta-analysis of association between the three genes and schizophrenia, which may implicate the involvement of TPH in the pathogenesis of schizophrenia, has potentially important clinical, scientific and public health implications as well as providing a putative basis for the study of hydroxylase-related drugs.
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TLDR
The results suggest that the polymorphic intron 1 of the human TH gene may be associated with disturbances of the catecholamine pathway in schizophrenia.
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TLDR
It is demonstrated that, in man, TH molecules are encoded by at least three distinct messenger RNAs, which could represent a novel means of regulating catecholamine levels in normal and pathological neurons.
Analysis of the 5’Region of the Human Tyrosine Hydroxylase Gene: Combinatorial Patterns of Exon Splicing Generate Multiple Regulated Tyrosine Hydroxylase Isoforms
TLDR
Comparison of the 5’flanking regions of human and rat genes discloses several highly conserved segments, likely to play an important role in the regulation of TH gene expression.
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TLDR
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