Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.

@article{Martens2005AssociationOD,
  title={Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.},
  author={John W. M. Martens and Inko Nimmrich and Thomas Koenig and Maxime P. Look and Nadia Harbeck and Fabian Model and Antje Kluth and Joan B. Bolt-de Vries and Anieta M. Sieuwerts and Henk Portengen and Marion E. Meijer-van Gelder and Christian Piepenbrock and Alexander Olek and Heinz Hoefler and Marion Kiechle and Jan G. M. Klijn and Manfred Schmitt and Sabine Maier and John A. Foekens},
  journal={Cancer research},
  year={2005},
  volume={65 10},
  pages={4101-17}
}
To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methylation in the promoter regions of genes is a prominent epigenetic gene silencing mechanism that contributes to breast cancer biology. In the current study, we investigated whether… CONTINUE READING

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Methylated genes as new cancer biomarkers

R. Napieralskic, J. W. M. Martensd, +5 authors M. Schmittc
2017

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