Association of Cytochrome P450 Enzymes is a Determining Factor in their Catalytic Activity

@article{Hazai2005AssociationOC,
  title={Association of Cytochrome P450 Enzymes is a Determining Factor in their Catalytic Activity},
  author={Eszter Hazai and Zsolt Bik{\'a}di and Mikl{\'o}s Simonyi and David Kupfer},
  journal={Journal of computer-aided molecular design},
  year={2005},
  volume={19 4},
  pages={271-85}
}
Previously, our laboratory demonstrated that one cytochrome P450 isoenzyme can influence the catalytic properties of another P450 isoenzyme when combined in a reconstituted system. Moreover, our data and that of other investigators indicate that P450 interaction is required for catalytic activity even when one isoenzyme is present. The goal of the current study was to examine the possible mechanism of these interactions in more detail. Analyzing recently published X-ray data of microsomal P450… CONTINUE READING

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