Association of CYP3A4*18B and CYP3A5*3 polymorphism with cyclosporine-related liver injury in Chinese renal transplant recipients.

@article{Xin2014AssociationOC,
  title={Association of CYP3A4*18B and CYP3A5*3 polymorphism with cyclosporine-related liver injury in Chinese renal transplant recipients.},
  author={Hua-wen Xin and Hui-ming Liu and Yuan-qi Li and Hui Huang and Li Zhang and Ai-rong Yu and Xiao-chun Wu},
  journal={International journal of clinical pharmacology and therapeutics},
  year={2014},
  volume={52 6},
  pages={497-503}
}
OBJECTIVE The purpose of this study was to investigate the associations between CYP3A4*18B and CYP3A5*3 polymorphism and cyclosporine-related liver injuries in Chinese renal transplant recipients. METHODS We genotyped 339 renal transplant recipients treated with a triple immunosuppressive regimen including cyclosporine for CYP3A4*18B and CYP3A5*3 polymorphism using the polymerase chain reaction restriction fragment length polymorphism assay. RESULTS The incidence of liver injury in the… CONTINUE READING