Association of CYP2R1 rs10766197 with MS risk and disease progression

  title={Association of CYP2R1 rs10766197 with MS risk and disease progression},
  author={Concetta Scazzone and L. Agnello and P. Ragonese and B. Lo Sasso and C. Bellia and G. Bivona and R. Schillaci and G. Salemi and M. Ciaccio},
  journal={Journal of Neuroscience Research},
  pages={297 - 304}
  • Concetta Scazzone, L. Agnello, +6 authors M. Ciaccio
  • Published 2018
  • Medicine
  • Journal of Neuroscience Research
  • BACKGROUND MS is a neurodegenerative autoimmune disease resulting from a complex interaction of genetic and environmental factors. [...] Key MethodMETHODS 25-OH-vitamin D3 levels and genotyping of CYP2R1- and NADSYN1-SNPs were investigated both in MS patients and in healthy controls. RESULTS The analysis revealed lower 25-OH-vitamin D3 concentrations in MS patients than in controls and an association of rs10766197 CYP2R1 SNP with MS risk. After stratifying MS patients according to gender, we found that the…Expand Abstract
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