Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects

@article{Kim2009AssociationOC,
  title={Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects},
  author={K. Kim and W. K. Song and J. Y. Park},
  journal={Clinical Pharmacology & Therapeutics},
  year={2009},
  volume={86}
}
  • K. Kim, W. K. Song, J. Y. Park
  • Published 2009
  • Biology, Medicine
  • Clinical Pharmacology & Therapeutics
    • We assessed the association of CYP2B6, CYP3A5, and CYP2C19 polymorphisms with sibutramine pharmacokinetics. Forty six healthy male subjects were enrolled, and their CYP2B6 (*4 and *6), CYP3A5 (*3), and CYP2C19 (*2, and *3) genotypes were analyzed. After a single 15‐mg dose of sibutramine was administered, plasma concentrations of sibutramine and its metabolites, M1 and M2, were measured. CYP2B6 and CYP3A5 polymorphisms did not affect the pharmacokinetics of sibutramine and its metabolites… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    21 Citations
    Highly Influential Citations
    4
    Background Citations
    8
    Results Citations
    2

    Topics from this paper

    Explore Further: Topics Discussed in This Paper

    21 Citations
    Citation Type

    Citation Type

    Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6*6 allele.
    • 7
    • Highly Influenced
    Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects
    • 15
    Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism
    • 5
    Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers
    • 17
    Effects of Clopidogrel on the Pharmacokinetics of Sibutramine and Its Active Metabolites
    • 13
    Different Effects of Clopidogrel and Clarithromycin on the Enantioselective Pharmacokinetics of Sibutramine and its Active Metabolites in Healthy Subjects
    • 5
    • Highly Influenced
    Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype–phenotype correlation in childhood
    • 33
    Enantioselective N-Demethylation and Hydroxylation of Sibutramine in Human Liver Microsomes and Recombinant Cytochrome P-450 Isoforms
    • 4
    In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates
    • 25
    Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development.
    • 186

    References

    SHOWING 1-10 OF 60 REFERENCES
    Effect of cytochrome P450 3A5*3 genotype on the stereoselective pharmacokinetics of amlodipine in healthy subjects.
    • 11
    Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.
    • 194
    Effect of Polymorphic CYP3A5 Genotype on the Single‐Dose Simvastatin Pharmacokinetics in Healthy Subjects
    • 84
    Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
    • 841
    Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
    • 34
    CYP2C19‐ and CYP3A4‐Dependent Omeprazole Metabolism in West Mexicans
    • 53
    Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population
    • 130
    Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects
    • 44
    The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance
    • 277
    Efavirenz Pharmacokinetics in HIV-1-Infected Children Are Associated With CYP2B6-G516T Polymorphism
    • 87