Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects
@article{Kim2009AssociationOC, title={Association of CYP2B6, CYP3A5, and CYP2C19 Genetic Polymorphisms With Sibutramine Pharmacokinetics in Healthy Korean Subjects}, author={K. Kim and W. K. Song and J. Y. Park}, journal={Clinical Pharmacology & Therapeutics}, year={2009}, volume={86} }
We assessed the association of CYP2B6, CYP3A5, and CYP2C19 polymorphisms with sibutramine pharmacokinetics. Forty six healthy male subjects were enrolled, and their CYP2B6 (*4 and *6), CYP3A5 (*3), and CYP2C19 (*2, and *3) genotypes were analyzed. After a single 15‐mg dose of sibutramine was administered, plasma concentrations of sibutramine and its metabolites, M1 and M2, were measured. CYP2B6 and CYP3A5 polymorphisms did not affect the pharmacokinetics of sibutramine and its metabolites… CONTINUE READING
Topics from this paper
21 Citations
Effects of CYP3A5, CYP2C19, and CYP2B6 on the clinical efficacy and adverse outcomes of sibutramine therapy: a crucial role for the CYP2B6*6 allele.
- Medicine
- Clinica chimica acta; international journal of clinical chemistry
- 2014
- 7
- Highly Influenced
Effect of CYP2B6 Genotype on the Pharmacokinetics of Sibutramine and Active Metabolites in Healthy Subjects
- Medicine
- Journal of clinical pharmacology
- 2011
- 15
Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism
- Chemistry, Medicine
- Xenobiotica; the fate of foreign compounds in biological systems
- 2013
- 5
Influence of ABCB1 and CYP3A5 genetic polymorphisms on the pharmacokinetics of quetiapine in healthy volunteers
- Medicine
- Pharmacogenetics and genomics
- 2014
- 17
Effects of Clopidogrel on the Pharmacokinetics of Sibutramine and Its Active Metabolites
- Medicine
- Journal of clinical pharmacology
- 2011
- 13
Different Effects of Clopidogrel and Clarithromycin on the Enantioselective Pharmacokinetics of Sibutramine and its Active Metabolites in Healthy Subjects
- Medicine
- Journal of clinical pharmacology
- 2013
- 5
- Highly Influenced
Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype–phenotype correlation in childhood
- Biology, Medicine
- European Journal of Clinical Pharmacology
- 2011
- 33
Enantioselective N-Demethylation and Hydroxylation of Sibutramine in Human Liver Microsomes and Recombinant Cytochrome P-450 Isoforms
- Chemistry, Medicine
- Journal of toxicology and environmental health. Part A
- 2014
- 4
In Vivo Quantitative Prediction of the Effect of Gene Polymorphisms and Drug Interactions on Drug Exposure for CYP2C19 Substrates
- Biology, Medicine
- The AAPS Journal
- 2012
- 25
Population differences in major functional polymorphisms of pharmacokinetics/pharmacodynamics-related genes in Eastern Asians and Europeans: implications in the clinical trials for novel drug development.
- Biology, Medicine
- Drug metabolism and pharmacokinetics
- 2012
- 186
References
SHOWING 1-10 OF 60 REFERENCES
Effect of cytochrome P450 3A5*3 genotype on the stereoselective pharmacokinetics of amlodipine in healthy subjects.
- Chemistry, Medicine
- Chirality
- 2009
- 11
Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population.
- Biology, Medicine
- Therapeutic drug monitoring
- 1998
- 194
Effect of Polymorphic CYP3A5 Genotype on the Single‐Dose Simvastatin Pharmacokinetics in Healthy Subjects
- Chemistry, Medicine
- Journal of clinical pharmacology
- 2007
- 84
Clinical Significance of the Cytochrome P450 2C19 Genetic Polymorphism
- Biology, Medicine
- Clinical pharmacokinetics
- 2002
- 841
Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa.
- Biology, Medicine
- British journal of clinical pharmacology
- 2009
- 34
CYP2C19‐ and CYP3A4‐Dependent Omeprazole Metabolism in West Mexicans
- Chemistry, Medicine
- Journal of clinical pharmacology
- 2003
- 53
Allele and genotype frequencies of CYP2B6 and CYP3A5 in the Japanese population
- Biology, Medicine
- European Journal of Clinical Pharmacology
- 2002
- 130
Effect of CYP3A5*3 genotype on the pharmacokinetics and antiplatelet effect of clopidogrel in healthy subjects
- Chemistry, Medicine
- European Journal of Clinical Pharmacology
- 2008
- 44
The Effect of CYP2C19 Polymorphism on the Pharmacokinetics and Pharmacodynamics of Clopidogrel: A Possible Mechanism for Clopidogrel Resistance
- Medicine
- Clinical pharmacology and therapeutics
- 2008
- 277
Efavirenz Pharmacokinetics in HIV-1-Infected Children Are Associated With CYP2B6-G516T Polymorphism
- Biology, Medicine
- Journal of acquired immune deficiency syndromes
- 2007
- 87