Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome.

@article{Barone2005AssociationOC,
  title={Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sj{\"o}gren's syndrome.},
  author={Francesca Barone and Michele Bombardieri and Antonio Manzo and Mark Blades and Peter Roger Morgan and S J Challacombe and Guido Valesini and Costantino Pitzalis},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 6},
  pages={1773-84}
}
OBJECTIVE Ectopic lymphoneogenesis can occur in the salivary glands of Sjögren's syndrome (SS) patients and is associated with local antigen-driven B cell responses, autoantibody formation, and potential lymphomatous transformation. CXCL13 and CCL21 have been identified in salivary glands, but their role in ectopic lymphoneogenesis in SS remains unclear. This study aimed to evaluate the microanatomic association between CXCL13 and CCL21 expression and the acquisition of lymphoid features in… CONTINUE READING
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