Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma.

  title={Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma.},
  author={Y K Wong and K M Chang and C Cheng and C-J Liu},
  journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology},
  volume={35 1},
BACKGROUND Oral squamous cell carcinoma (OSCC) is a worldwide problem. The main mechanism of tumor immunity is the destruction of tumor cells by cytolytic T lymphocytes. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4; CD152), a negative regulator of T-lymphocyte activation, plays an extremely important role in the immune tolerance and anergy. This study was designed to investigate the role of CTLA-4 polymorphism in OSCC. METHODS The CTLA-4 +49 A/G polymorphism was studied in 118 patients… CONTINUE READING

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Associations between CTLA-4 +49 A/G (rs231775) polymorphism and cancer risk: a meta-analysis based on 52 case-control studies.

International journal of clinical and experimental medicine • 2015
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