Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population.

@article{Awata1998AssociationOC,
  title={Association of CTLA-4 gene A-G polymorphism (IDDM12 locus) with acute-onset and insulin-depleted IDDM as well as autoimmune thyroid disease (Graves' disease and Hashimoto's thyroiditis) in the Japanese population.},
  author={T Awata and S Kurihara and M Iitaka and S Takei and I Inoue and C Ishii and K Negishi and T Izumida and Y Yoshida and Ryoko Hagura and N Kuzuya and Y Kanazawa and S Katayama},
  journal={Diabetes},
  year={1998},
  volume={47 1},
  pages={128-9}
}
  • T Awata, S Kurihara, +10 authors S Katayama
  • Published 1998 in Diabetes
Both IDDM and autoimmune thyroid disease (AITD; Graves' disease or Hashimoto's thyroiditis) are believed to develop through a T-cell-mediated autoimmune process, and genetic factors clearly play an important role in this process. To date, studies have shown that the development of IDDM is controlled by multiple susceptibility genes, including HLA class II genes (IDDM1) and a variable number of tandem repeats (VNTR) near the insulin gene (IDDM2) (1). Less is known about AITD susceptibility genes… CONTINUE READING