Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

@article{Corneveaux2010AssociationOC,
  title={Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.},
  author={Jason J. Corneveaux and Amanda J. Myers and April N. Allen and Jeremy Pruzin and Manuel Ram{\'i}rez and Anzhelika Engel and Michael A. Nalls and Kewei Chen and Wendy Lee and Kendria Chewning and Stephen Villa and Hunsar B Meechoovet and Jill D. Gerber and Danielle Frost and Hollie L Benson and S. B. O'Reilly and Lori B. Chibnik and Joshua M Shulman and Andrew Singleton and David W. Craig and Kendall R Van Keuren-Jensen and Travis Dunckley and David A. Bennett and Philip L De Jager and Christopher B. Heward and John S. Hardy and Eric M. Reiman and Matthew J. Huentelman},
  journal={Human molecular genetics},
  year={2010},
  volume={19 16},
  pages={3295-301}
}
In this study, we assess 34 of the most replicated genetic associations for Alzheimer's disease (AD) using data generated on Affymetrix SNP 6.0 arrays and imputed at over 5.7 million markers from a unique cohort of over 1600 neuropathologically defined AD cases and controls (1019 cases and 591 controls). Testing the top genes from the AlzGene meta-analysis, we confirm the well-known association with APOE single nucleotide polymorphisms (SNPs), the CLU, PICALM and CR1 SNPs recently implicated in… CONTINUE READING
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