Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence

@article{Dick2007AssociationOC,
  title={Association of CHRM2 with IQ: Converging Evidence for a Gene Influencing Intelligence},
  author={Danielle M. Dick and F. Aliev and J. Kramer and Jen C. Wang and A. Hinrichs and S. Bertelsen and S. Kuperman and M. Schuckit and John I Nurnberger and H. Edenberg and B. Porjesz and H. Begleiter and V. Hesselbrock and A. Goate and L. Bierut},
  journal={Behavior Genetics},
  year={2007},
  volume={37},
  pages={265-272}
}
  • Danielle M. Dick, F. Aliev, +12 authors L. Bierut
  • Published 2007
  • Psychology, Medicine
  • Behavior Genetics
  • The cholinergic neurotransmitter system is thought to be involved in many aspects of memory, attention, and higher cognition. In the Collaborative Study on the Genetics of Alcoholism (COGA) sample, we have previously reported linkage and association to the cholinergic muscarinic 2 receptor gene (CHRM2) on chromosome 7 with evoked EEG oscillations (Jones et al. 2004), providing evidence that this gene may be involved in human brain dynamics and cognition. In addition, a small number of genetic… CONTINUE READING
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    References

    SHOWING 1-10 OF 33 REFERENCES
    Association between the CHRM2 gene and intelligence in a sample of 304 Dutch families
    • 56
    • PDF
    Role of the cholinergic muscarinic 2 receptor (CHRM2) gene in cognition
    • 81
    • Highly Influential
    • PDF
    Linkage Analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) Sample
    • 39
    • PDF
    Cognitive Traits Link to Human Chromosomal Regions
    • 37
    A Quantitative Trait Locus Not Associated with Cognitive Ability in Children: A Failure to Replicate
    • 31
    • PDF
    Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome.
    • 286
    • PDF
    The genetic basis of cognition.
    • J. Flint
    • Biology, Medicine
    • Brain : a journal of neurology
    • 1999
    • 74
    • PDF
    Linkage and linkage disequilibrium of evoked EEG oscillations with CHRM2 receptor gene polymorphisms: implications for human brain dynamics and cognition.
    • K. Jones, B. Porjesz, +24 authors H. Begleiter
    • Medicine, Psychology
    • International journal of psychophysiology : official journal of the International Organization of Psychophysiology
    • 2004
    • 143
    • PDF
    A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p.
    • 139
    • Highly Influential
    • PDF
    Cathepsin D exon 2 polymorphism associated with general intelligence in a healthy older population
    • 53
    • PDF