Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration.

@article{Seddon2007AssociationOC,
  title={Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration.},
  author={Johanna M. Seddon and Peter Francis and Sarah J George and Dennis W. Schultz and Bernard Rosner and Michael L. Klein},
  journal={JAMA},
  year={2007},
  volume={297 16},
  pages={1793-800}
}
CONTEXT Studies have reported that single-nucleotide polymorphisms in the genes CFH and LOC387715 are associated with age-related macular degeneration (AMD). OBJECTIVE To assess whether these genetic variants have prognostic importance for progression to advanced AMD and related visual loss. DESIGN, SETTING, AND PARTICIPANTS Prospective analysis of 1466 white participants in the Age-Related Eye Disease Study (AREDS), a US multicenter clinical trial conducted from 1990 to 2001 with a mean… CONTINUE READING
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