Association of CD28 and CTLA-4 gene polymorphisms with aggressive periodontitis in Brazilians.

@article{Silva2013AssociationOC,
  title={Association of CD28 and CTLA-4 gene polymorphisms with aggressive periodontitis in Brazilians.},
  author={M R M A e Silva and Paula Rocha Moreira and Germano Carneiro da Costa and Adriana Machado Saraiva and Paulo Eduardo Alencar de Souza and S A F Amormino and Jos{\'e} Eust{\'a}quio da Costa and K J Gollob and Walderez O Dutra},
  journal={Oral diseases},
  year={2013},
  volume={19 6},
  pages={568-76}
}
OBJECTIVE Susceptibility to and severity of periodontal disease is influenced by gene polymorphisms related to the immune response. Co-stimulatory molecules, such as CD28 and CTLA-4, are critical in the development of such responses. Our hypothesis is that polymorphisms in genes that code for these molecules may be associated with periodontitis. The aim of the study was to investigate the association between +17 (T/C) CD28 and +49 (A/G) CTLA-4 gene polymorphisms and periodontitis in Brazilians… CONTINUE READING
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