Association of CD247 with systemic lupus erythematosus in Asian populations.

@article{Li2012AssociationOC,
  title={Association of CD247 with systemic lupus erythematosus in Asian populations.},
  author={Ruifeng Li and Wenlong Yang and Jianfeng Zhang and Nattiya Hirankarn and H-F Pan and C C Mok and T. M. Chan and Raymond Woon Sing Wong and Mo Yin Mok and Ka Wing Lee and Sik Nin Wong and Alexander Moon Ho Leung and X-P Li and Yingyos Avihingsanon and Tsz Leung Lee and Marco Hok Kung Ho and Pamela Pui Wah Lee and Wilfred Hing Sang Wong and C. Wong and Irene O.L. Ng and Jinghua Yang and Philip Hei Li and Yu Zhang and Lijun Zhang and Wei-yang Li and L. Baum and Patrick C. F. Kwan and Pornpimol Rianthavorn and Thavatchai Deekajorndej and Kanya Suphapeetiporn and Vorasuk Shotelersuk and M-M Garcia-Barcel{\'o} and Stacey Shawn Cherny and Po-lai Tam and Pak Chung Sham and Chak Sing Lau and Ningning Shen and Yu Lung Lau and D. H Ye},
  journal={Lupus},
  year={2012},
  volume={21 1},
  pages={
          75-83
        }
}
OBJECTIVE Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. CD247 (CD3Z, TCRZ) plays a vital role in antigen recognition and signal transduction in antigen-specific immune responses, and is known to be involved in SLE pathogenesis. Weak disease association was reported for genetic variants in this gene in Caucasian studies for SLE, Crohn's disease and systemic sclerosis, but its role as a genetic risk factor was never firmly established… CONTINUE READING

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