Association of CD247 with systemic lupus erythematosus in Asian populations

  title={Association of CD247 with systemic lupus erythematosus in Asian populations},
  author={R. Li and W. Yang and J. Zhang and N. Hirankarn and H-F Pan and C. C. Mok and T. Chan and R. Wong and M. Y. Mok and K. W. Lee and S. N. Wong and A. M. H. Leung and X-P Li and Y. Avihingsanon and T. Lee and M. Ho and P. Lee and W. Wong and C-M Wong and I. Ng and J. Yang and P. H. Li and Y. Zhang and L. Zhang and W. Li and L. Baum and P. Kwan and P. Rianthavorn and T. Deekajorndej and K. Suphapeetiporn and V. Shotelersuk and M. Garcia-Barcelo and S. Cherny and P. Tam and P. Sham and C. Lau and N. Shen and Y. L. Lau and D. Ye},
  pages={75 - 83}
  • R. Li, W. Yang, +36 authors D. Ye
  • Published 2012
  • Medicine
  • Lupus
  • Objective: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease with complex genetic inheritance. CD247 (CD3Z, TCRZ) plays a vital role in antigen recognition and signal transduction in antigen-specific immune responses, and is known to be involved in SLE pathogenesis. Weak disease association was reported for genetic variants in this gene in Caucasian studies for SLE, Crohn's disease and systemic sclerosis, but its role as a genetic risk factor was never firmly established… CONTINUE READING
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