Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses.

  title={Association of CD14 promoter polymorphism with otitis media and pneumococcal vaccine responses.},
  author={Selma P. Wiertsema and S-K Khoo and Gareth Baynam and Reinier H. Veenhoven and Ingrid Alisa Laing and Gerhard A. Zielhuis and Ger T. Rijkers and Jack Goldblatt and Peter N Lesou{\"e}f and Elisabeth A. M. Sanders},
  journal={Clinical and vaccine immunology : CVI},
  volume={13 8},
Innate immunity is of particular importance for protection against infection during early life, when adaptive immune responses are immature. CD14 plays key roles in innate immunity, including in defense against pathogens associated with otitis media, a major pediatric health care issue. The T allele of the CD14 C-159T polymorphism has been associated with increased serum CD14 levels. Our objective was to investigate the hypothesis that the CD14 C-159T allele is protective against recurrent… CONTINUE READING
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