Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.

@article{Nadif2005AssociationOC,
  title={Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli.},
  author={Rachel Nadif and Margaret Mintz and Anne Jedlicka and J Bertrand and Steven R. Kleeberger and Francine Kauffmann},
  journal={Free radical research},
  year={2005},
  volume={39 12},
  pages={1345-50}
}
We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (-262;-844), and by their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, NcoI) and tumor necrosis factor (TNF, -308) in 196 miners. Erythrocyte catalase, superoxide dismutase, and glutathione peroxidase activities were measured. The CAT -262 SNP was related to lower catalase activity (104, 87 and 72 k/g hemoglobin for CC, CT and TT, respectively, p < 0… CONTINUE READING