Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

  title={Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells},
  author={R. Scully and J. Chen and A. Plug and Y. Xiao and D. Weaver and J. Feunteun and T. Ashley and D. Livingston},
  • R. Scully, J. Chen, +5 authors D. Livingston
  • Published 1997
  • Biology, Medicine
  • Cell
  • BRCA1 immunostaining reveals discrete, nuclear foci during S phase of the cell cycle. Human Rad51, a homolog of bacterial RecA, behaves similarly. The two proteins were found to colocalize in vivo and to coimmunoprecipitate. BRCA1 residues 758-1064 alone formed Rad51-containing complexes in vitro. Rad51 is also specifically associated with developing synaptonemal complexes in meiotic cells, and BRCA1 and Rad51 were both detected on asynapsed (axial) elements of human synaptonemal complexes… CONTINUE READING

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