Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

@article{Lesch1996AssociationOA,
  title={Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region},
  author={K. Lesch and D. Bengel and A. Heils and S. Z. Sabol and B. Greenberg and S. Petri and J. Benjamin and C. M{\"u}ller and D. Hamer and D. Murphy},
  journal={Science},
  year={1996},
  volume={274},
  pages={1527 - 1531}
}
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression… Expand
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