Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

@article{Lesch1996AssociationOA,
  title={Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region},
  author={Klaus-Peter Lesch and Dietmar Bengel and Armin Heils and Sue Z. Sabol and Benjamin D. Greenberg and Susanne Petri and Jonathan Benjamin and Clemens R. Müller and Dean Hamer and Dennis L. Murphy},
  journal={Science},
  year={1996},
  volume={274},
  pages={1527 - 1531}
}
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression… 
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Transporter-assisted uptake of serotonin (5-HT) and dopamine (DA) and their relations to psychiatric disorders are described.
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