Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region

@article{Lesch1996AssociationOA,
  title={Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region},
  author={K. P. Lesch and D. Bengel and A. Heils and S. Z. Sabol and B. Greenberg and S. Petri and J. Benjamin and C. R. Mueller and D. Hamer and D. Murphy},
  journal={Science},
  year={1996},
  volume={274},
  pages={1527 - 1531}
}
  • K. P. Lesch, D. Bengel, +7 authors D. Murphy
  • Published 1996
  • Biology, Medicine
  • Science
    • Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression… CONTINUE READING
    View on AAAS
    ncbi.nlm.nih.gov
    4,886 Citations
    Highly Influencial Citations
    342
    Background Citations
    2,047
    Methods Citations
    228
    Results Citations
    205

    Paper Mentions

    News Article
    Massive Study Debunks Claim That There's a Single Gene For Depression
    Science Alert
    4 April 2019
    Blog Post
    Can flies teach us something about the genetics and potential treatments for anxiety? Surprising new findings about similarities with humans.
    the neurosphere
    9 April 2016
    Observational Clinical Trial
    Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders
    This study will investigate how the brain process emotions in healthy people and in patients who have major depression in order to better understand the causes of depression. It will… Expand
    ConditionsDepressive Disorder, Major
    National Institutes of Health Clinical Center (CC)
    November 2004 - January 2014
    Blog Post
    Scaredy Cat? Blame it on your genes (Again!!)
    Wissenschaft
    13 August 2009
    Blog Post
    A Very Optimistic Genetics Paper
    Neuroskeptic
    2 March 2009
    Blog Post
    Perosnality and Neurotransmitters
    The Mouse Trap
    22 January 2009
    Blog Post
    NOS1 - An Impulsivity Gene?
    Neuroskeptic
    16 January 2009
    4,886 Citations
    Citation Type

    Citation Type

    Anxiety traits associated with a polymorphism in the serotonin transporter gene regulatory region in the Japanese
    • 104
    • PDF
    The human serotonin transporter gene polymorphism-basic research and clinical implications
    • 164
    Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism.
    • 132
    • Highly Influenced
    Mouse model of the human serotonin transporter-linked polymorphic region
    • PDF
    Polymorphism of the Serotonin Transporter
    • 62
    The role of the serotonin transporter polymorphism for the endocrine stress response in newborns
    • 85
    • Highly Influenced
    • PDF
    Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse.
    • 30
    Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets.
    • 519
    No Association of a Functional Polymorphism in the Serotonin Transporter Gene Promoter and Anxiety-Related Personality Traits
    • 40
    A novel allele in the promoter region of the human serotonin transporter gene
    • 56
    • PDF

    References

    SHOWING 1-10 OF 62 REFERENCES
    Polymorphism in serotonin transporter gene associated with susceptibility to major depression
    • 506
    Primary structure of the serotonin transporter in unipolar depression and bipolar disorder
    • 118
    Allelic Variation of Human Serotonin Transporter Gene Expression
    • 2,117
    Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter.
    • 848
    5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research.
    • G. Griebel
    • Biology, Medicine
    • Pharmacology & therapeutics
    • 1995
    • 447
    The serotonin transporter is a potential susceptibility factor for bipolar affective disorder.
    • 195
    Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking
    • 1,133
    • PDF
    Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization.
    • 829
    • PDF
    Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking
    • 1,393
    Biological dissection of anxiety disorders: the clinical role of selective serotonin reuptake inhibitors with particular reference to fluvoxamine
    • 25