Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
@article{Lesch1996AssociationOA, title={Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region}, author={K. P. Lesch and D. Bengel and A. Heils and S. Z. Sabol and B. Greenberg and S. Petri and J. Benjamin and C. R. Mueller and D. Hamer and D. Murphy}, journal={Science}, year={1996}, volume={274}, pages={1527 - 1531} }
Transporter-facilitated uptake of serotonin (5-hydroxytryptamine or 5-HT) has been implicated in anxiety in humans and animal models and is the site of action of widely used uptake-inhibiting antidepressant and antianxiety drugs. Human 5-HT transporter (5-HTT) gene transcription is modulated by a common polymorphism in its upstream regulatory region. The short variant of the polymorphism reduces the transcriptional efficiency of the 5-HTT gene promoter, resulting in decreased 5-HTT expression… CONTINUE READING
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