Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine.

@article{Chang2015AssociationOA,
  title={Association of ARRB1 polymorphisms with the risk of major depressive disorder and with treatment response to mirtazapine.},
  author={Hun Soo Chang and Eun Soo Won and Hwa-Young Lee and Byung-Joo Ham and Yong-Gu Kim and Min-Soo Lee},
  journal={Journal of psychopharmacology},
  year={2015},
  volume={29 5},
  pages={615-22}
}
β-Arrestin 1 is known to be involved in the pathophysiology of major depressive disorder (MDD) and in the underlying mechanism of action of antidepressant therapies. After we screened 39 ARRB1 polymorphisms, we investigated the associations of seven ARRB1 single-nucleotide polymorphisms (SNPs) with the risk of MDD in 270 patients with MDD and 204 normal subjects, and with mirtazapine treatment response in patients with MDD. The genotype distributions of -132C>T and IVS1+85T>C showed significant… CONTINUE READING
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