Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression.

@article{Hwang2006AssociationOA,
  title={Association of APOE genetic polymorphism with cognitive function and suicide history in geriatric depression.},
  author={J P Hwang and Chen-Hong Yang and C N Hong and Jiing-Feng Lirng and Ya-Min Yang and Shih-Jen Tsai},
  journal={Dementia and geriatric cognitive disorders},
  year={2006},
  volume={22 4},
  pages={334-8}
}
Apolipoprotein E (APOE) has been associated with a variety of late-life neuropsychiatric disorders, including geriatric depression. This study determined whether APOE genotypes affect vulnerability to geriatric depression. We also tested the effect of the presence of the APOE epsilon4 (APOE4) allele on age of onset, suicide attempt history and cognitive function in geriatric depressed patients. We genotyped APOE in 111 elderly inpatients diagnosed as having major depression and 144 normal… CONTINUE READING
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