Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients.

@article{Charrire2008AssociationOA,
  title={Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients.},
  author={Sybil Charri{\`e}re and Sophie Bernard and Mahdi Aqallal and Micheline Merlin and St{\'e}phane Billon and Laurence Perrot and Elodie Le Coquil and Agn{\`e}s Sassolas and Philippe Moulin and Christophe Marçais},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2008},
  volume={394 1-2},
  pages={99-103}
}
BACKGROUND Two minor apolipoprotein A5 (APOA5) gene haplotypes, represented by -1131T>C and S19W polymorphisms, are strong determinants of plasma triglyceride (TG) concentration variability across human populations. Hypertriglyceridemia is frequent in type 2 diabetes (T2D) and hyperchylomicronemia is not uncommon. METHODS We investigated the association of -1131T>C and S19W polymorphisms with diabetic dyslipidemia in 400 Caucasian T2D patients divided in 2 groups: group N with 130… CONTINUE READING

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