Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population.

@article{Ermakov2010AssociationOA,
  title={Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population.},
  author={S. Ermakov and M. Toliat and Z. Cohen and I. Malkin and J. Altm{\"u}ller and G. Livshits and P. N{\"u}rnberg},
  journal={Bone},
  year={2010},
  volume={46 5},
  pages={
          1244-50
        }
}
Mineralization of the extracellular matrix of bone is an essential element of bone development, maintenance and repair. ALPL and ENPP1 genes and their products are known to be central in local regulation of bone mineralization. The present study investigates potential associations of ENPP1 and ALPL polymorphisms with several phenotypes reflecting bone size and hand BMD. The study sample included 310 Caucasian nuclear families. Forty SNPs in ALPL and 14 SNPs in ENPP1 genetic loci as well as… Expand
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