Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case–control study

@article{Gu2012AssociationOA,
  title={Association of ADAMTS5 gene polymorphisms with osteoarthritis in Chinese Han population: a community-based case–control study},
  author={Jiaao Gu and Jiesheng Rong and Fulin Guan and Liying Jiang and Ting Zhang and Shuqing Tao and Guofa Guan and Liang Xu and Tianzun Tao},
  journal={Rheumatology International},
  year={2012},
  volume={33},
  pages={2893-2897}
}
Aggrecanase-2 (ADAMTS5) is reported to play essential roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between ADAMTS5 gene polymorphisms and primary OA, we conducted a community-based case–control study. A total of 732 community residents aged 40–84 years participated in the community-based study in Northeast China. After taking physical examination and radiographic examination, 420 persons of the residents were diagnosed OA (216 women and 204 men). The other… CONTINUE READING

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