Association of ABCG1 With Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese.

@article{Ma2016AssociationOA,
  title={Association of ABCG1 With Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in Chinese and Japanese.},
  author={Li Ma and Ke Liu and Motokazu Tsujikawa and Haoyu Chen and M{\aa}rten Erik Brel{\'e}n and Vesta C. K. Chan and Timothy Y Y Lai and Kaori Sayanagi and Chicako Hara and Noriyasu Hashida and Pancy O S Tam and Alvin L Young and Wei-qi Chen and Kohji Nishida and Chi Pui Pang and Li Jia Chen},
  journal={Investigative ophthalmology & visual science},
  year={2016},
  volume={57 13},
  pages={5758-5763}
}
Purpose We investigated the association of the ATP-binding cassette, subfamily G, member 1 (ABCG1) gene with polypoidal choroidal vasculopathy (PCV) and neovascular age-related macular degeneration (nAMD) in independent Chinese and Japanese cohorts. Methods A total of 12 haplotype-tagging single-nucleotide polymorphisms (SNPs) and the SNP rs57137919 in the ABCG1 gene were first analyzed in a Hong Kong Chinese cohort of 235 nAMD, 236 PCV, and 365 controls, using TaqMan genotyping assays. Two… CONTINUE READING

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