Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.


Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer's disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study.

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@article{Li2004AssociationOA, title={Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study.}, author={Yonghong Li and Kristina M. Tacey and Lisa M. Doil and Ryan van Luchene and Ver{\'o}nica Edith Garc{\'i}a and Charles Rowland and Steve Schrodi and Diane U Leong and Kit F. Lau and Joe Catanese and John Sninsky and P. Nowotny and Peter Holmans and John Hardy and John Francis Powell and Simon Lovestone and Leon Thal and Michael J. Owen and Julie Williams and Alison M. Goate and Andrew Grupe}, journal={Neuroscience letters}, year={2004}, volume={366 3}, pages={268-71} }