Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease.

@article{Vilar2007AssociationOA,
  title={Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease.},
  author={Rui M. Vilar and H Coelho and Edrich Joseph Rodrigues and Maria Jo{\~a}o Gama and Ivelisse Rivera and Emanuela Taioli and Maria Celeste Lechner},
  journal={European journal of neurology},
  year={2007},
  volume={14 2},
  pages={156-61}
}
Genetic predisposition, environmental toxins and aging contribute to Parkinson's disease (PD) multifactorial etiology. Weak environmental neurotoxic factors may accumulate over time increasing the disease risk in genetically predisposed subjects. Polymorphic genes encoding drug-metabolizing-enzymes (DMEs) are considered to account for PD susceptibility by determining individual toxic response variability. In this work, the allelic distributions and genotype associations of three major brain… CONTINUE READING