Association of 150‐kDa oxygen‐regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy

@article{AbuElAsrar2018AssociationO1,
  title={Association of 150‐kDa oxygen‐regulated protein with vascular endothelial growth factor in proliferative diabetic retinopathy},
  author={Ahmed M. Abu El-Asrar and Ajmal Ahmad and Kaiser Alam and Emilie Bittoun and Mohammad Mairaj Siddiquei and Ghulam Mohammad and Ahmed Mousa and Gert De Hertogh and Ghislain Opdenakker},
  journal={Acta Ophthalmologica},
  year={2018},
  volume={96}
}
150‐kDa oxygen‐regulated protein (ORP150), a member of heat‐shock protein family located in endoplasmic reticulum (ER), has a critical role in secretion of vascular endothelial growth factor (VEGF). We investigated expression levels of ORP150 and correlated these levels with VEGF and total vitreous antioxidant capacity (TAC) in proliferative diabetic retinopathy (PDR). We also examined expression of ORP150 in retinas of diabetic rats and in human retinal microvascular endothelial cells (HRMEC). 

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