Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.

@article{Chamorro2012AssociationO,
  title={Association of µ-opioid receptor (OPRM1) gene polymorphism with response to naltrexone in alcohol dependence: a systematic review and meta-analysis.},
  author={A Chamorro and Miguel Marcos and Jos{\'e}-Antonio Mir{\'o}n-Canelo and Isabel J Pastor and Rogelio Gonz{\'a}lez-Sarmiento and F Javier Laso},
  journal={Addiction biology},
  year={2012},
  volume={17 3},
  pages={505-12}
}
Previous studies have suggested that the effect of naltrexone in patients with alcohol dependence may be moderated by genetic factors. In particular, the possession of the G allele of the A118G polymorphism of the µ-opioid receptor gene (OPRM1) has been associated with a better response to naltrexone, although controversial results have been reported. The aim of this paper is to combine previous findings by means of a systematic review and a meta-analysis. We retrieved studies on the… CONTINUE READING

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