Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.

  title={Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.},
  author={J. Y. Wan and K. Edwards and C. Hutter and I. F. Mata and A. Samii and John W. Roberts and P. Agarwal and H. Checkoway and F. Farin and D. Yearout and C. Zabetian},
  journal={Parkinsonism & related disorders},
  volume={20 1},
  • J. Y. Wan, K. Edwards, +8 authors C. Zabetian
  • Published 2014
  • Biology, Medicine
  • Parkinsonism & related disorders
  • BACKGROUND Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD). METHODS We sought to identify new PD susceptibility genes and to validate previously nominated candidate genes within the PARK10 region using a two-stage design. We used data from a large, publicly-available genome-wide association study (GWAS) in the discovery stage (n = 2000 cases and… CONTINUE READING
    14 Citations
    Advances in understanding genomic markers and pharmacogenetics of Parkinson’s disease
    • 22
    Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein
    • 93


    Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
    • 66
    Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra
    • 48
    Genomewide association study for onset age in Parkinson disease
    • 95
    • PDF
    Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
    • 1,526
    • PDF
    Genome-wide association study confirms extant PD risk loci among the Dutch
    • 147
    • PDF