Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.

@article{Wan2014AssociationMO,
  title={Association mapping of the PARK10 region for Parkinson's disease susceptibility genes.},
  author={J. Y. Wan and K. Edwards and C. Hutter and I. F. Mata and A. Samii and John W. Roberts and P. Agarwal and H. Checkoway and F. Farin and D. Yearout and C. Zabetian},
  journal={Parkinsonism & related disorders},
  year={2014},
  volume={20 1},
  pages={
          93-8
        }
}
  • J. Y. Wan, K. Edwards, +8 authors C. Zabetian
  • Published 2014
  • Biology, Medicine
  • Parkinsonism & related disorders
  • BACKGROUND Previous studies indicate that as many as six genes within the PARK10 region (RNF11, UQCRH, HIVEP3, EIF2B3, USP24, ELAVL4) might modify susceptibility or age at onset in Parkinson's disease (PD). METHODS We sought to identify new PD susceptibility genes and to validate previously nominated candidate genes within the PARK10 region using a two-stage design. We used data from a large, publicly-available genome-wide association study (GWAS) in the discovery stage (n = 2000 cases and… CONTINUE READING
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