Association mapping: critical considerations shift from genotyping to experimental design.

@article{Myles2009AssociationMC,
  title={Association mapping: critical considerations shift from genotyping to experimental design.},
  author={Sean Myles and Jason Peiffer and P J Brown and Elhan S. Ersoz and Zhiwu Zhang and Denise E. Costich and Edward S. Buckler},
  journal={The Plant cell},
  year={2009},
  volume={21 8},
  pages={2194-202}
}
The goal of many plant scientists' research is to explain natural phenotypic variation in terms of simple changes in DNA sequence. Traditionally, linkage mapping has been the most commonly employed method to reach this goal: experimental crosses are made to generate a family with known relatedness, and attempts are made to identify cosegregation of genetic markers and phenotypes within this family. In vertebrate systems, association mapping (also known as linkage disequilibrium mapping) is… CONTINUE READING
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