Association between vitamin D receptor, CCR5, TNF-α and TNF-β gene polymorphisms and HBV infection and severity of liver disease

@inproceedings{Suneetha2006AssociationBV,
  title={Association between vitamin D receptor, CCR5, TNF-α and TNF-β gene polymorphisms and HBV infection and severity of liver disease},
  author={Pothakamuri Venkata Suneetha and Shiv Kumar Sarin and Ankur Goyal and Gollapudi Tharun Kumar and Deepak Kumar Shukla and S. Syeed Hissar},
  year={2006}
}
Background/Aims: 1,25-dihydroxyvitamin-D is involved in immunomodulation. Expression of vitamin-D receptors in hepatocytes suggests its role in hepatocellular injury. We studied the association of single nucleotide polymorphisms in genes involved in immunoregulatory functions of vitamin-D with susceptibility, severity and persistence of HBV infection. Methods: Five polymorphisms in VDR, CCR5, TNF-a and TNF-b were studied in 214 chronic hepatitis B patients and 408 controls. Clinical parameters… CONTINUE READING
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