Association between variants of mast cell chymase gene and serum IgE levels in eczema.

Abstract

851 school children aged at 12-13 years including 145 with eczema were tested for genetic association to a mast cell chymase (MCC) genetic variant. MCC genotypes showed a strong association with eczema, but not with asthma and rhinitis. This association is strongest in eczematous children with lower serum total IgE levels. Independent of IgE responsiveness… (More)

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Cite this paper

@article{Mao1998AssociationBV, title={Association between variants of mast cell chymase gene and serum IgE levels in eczema.}, author={X Q Mao and Tetsuo Shirakawa and T. Enomoto and Shin-ichiro Shimazu and Yoshihiro Dake and Hirokazu Kitano and Akihito Hagihara and Julian M. Hopkin}, journal={Human heredity}, year={1998}, volume={48 1}, pages={38-41} }